Lymphoma Division

Diffuse Large Cell Lymphoma

ICD 9 Codes
199.2
200.00
200.01
200.02
200.03
200.04
200.05
200.06
200.07
200.08
200.10
200.11
200.12
200.13
200.14
200.15
200.16
200.17
200.18
200.50
200.51
200.52
200.53
200.54
200.55
200.56
200.57
200.58
200.60
200.61
200.62
200.63
200.64
200.65
200.66
200.67
200.68
202.80
202.81
202.83
202.84
202.85
202.86
202.87
202.88
202.30
202.31
202.32
202.33
202.34
202.35
202.36
202.37
202.38
238.77

Diagnostic Work Up
Exam/Test
Clinical Assessment/Evaluation Including:
~ History & Physical
~ Nodal areas
~ B Cell Symptoms
~ Splenomegaly
~ Hepatomegaly
~ Staging and IPI Annotation
CBC
Chemistry Panel
LDH
Uric Acid
LFTs
Hepatitis B and C testing
HIV testing
Flow PBL (Optional)
beta2microglobulin (Optional)
Ig level (Optional)
Beta HCG when applicable (Optional)
Lymph node tissue biopsy (FNA not sufficient)
Bone marrow biopsy (bilateral or unilateral) if > 2 cm core
Immunophenotype:
~ IHC: CD3, CD5, CD10, CD19, CD20, BCl- 2, BCl- 6, MIB1 (KI- 67), MUM- 1
~ Flow cytometry: kappa/lambda, CD3, CD5, CD10, CD19, CD20, CD45
Molecular studies (as needed/indicated):
~ BCR, BcI- 2, BcI- 1 rearrangement
~ FISH/cytogenetics: t(14;18), t(3;v), t(8;14)
CT Chest/Abdomen/Pelvis with contrast
PET Scan
Muga Scan
CT Neck with contrast (Optional)
MRI Sinus/Orbits/Base of Skull if indicated (Optional)
Endoscopies: upper GI evaluation if tonsil involvement
CSF evaluation (and prophylaxis) in the following situations:
~ Location: testicular, breast, renal, sinus, paraspinal, peri-orbital
~ Extra nodal disease with 2 to 3 sites, extensive bone marrow involvement
~ Context: HIV

Prognostic Work Up

Follicular Lymphoma

ICD 9 Codes
199.2
200.00
200.01
200.02
200.03
200.04
200.05
200.06
200.07
200.08
200.10
200.11
200.12
200.13
200.14
200.15
200.16
200.17
200.18
200.50
200.51
200.52
200.53
200.54
200.55
200.56
200.57
200.58
200.60
200.61
200.62
200.63
200.64
200.65
200.66
200.67
200.68
200.80
200.81
200.82
200.83
200.84
200.85
200.86
200.87
200.88
202.00
202.01
202.02
202.03
202.04
202.05
202.06
202.07
202.08
202.30
202.31
202.32
202.33
202.34
202.35
202.36
202.37
202.38
238.77

Diagnostic Work Up
Exam/Test
Clinical Assessment/Evaluation Including:
~ History & Physical
~ Nodal areas
~ B Cell Symptoms
~ Splenomegaly
~ Hepatomegaly
~ Staging and IPI Annotation: FLIPI score
CBC
Chemistry Panel
LDH
Uric Acid
LFTs
Hepatitis B and C testing
HIV testing
Flow PBL (Optional)
beta2microglobulin (Optional)
Ig level (Optional)
Beta HCG when applicable (Optional)
PCR for minimal residual disease (as part of research) (Optional)
Lymph node tissue biopsy (FNA not sufficient)
Bone marrow biopsy (bilateral or unilateral) if > 2 cm core
Immunophenotype:
~ IHC: CD3, CD5, CD10, CD19, CD20, CD 21, CD23, BCl- 2, BCl- 6, KI67, cyclin D1
~ Flow cytometry: kappa/lambda, CD3, CD5, CD10, CD19, CD20, CD23
Molecular studies (as needed/indicated):
~ BCR, BcI- 2 rearrangement
~ FISH/cytogenetics: t(14;18), t(8;14)
CT Chest/Abdomen/Pelvis with contrast
PET Scan (can guide for additional biopsy to R/O transformation
Muga Scan
CT Neck with contrast if indicated (Optional)
MRI Sinus/Orbits/Base of Skull if indicated (Optional)

Prognostic Work Up

Gastric MALT

ICD 9 Codes
199.2
200.00
200.01
200.02
200.03
200.04
200.05
200.06
200.07
200.08
200.10
200.11
200.12
200.13
200.14
200.15
200.16
200.17
200.18
200.50
200.51
200.52
200.53
200.54
200.55
200.56
200.57
200.58
200.60
200.61
200.62
200.63
200.64
200.65
200.66
200.67
200.68
200.80
200.81
200.82
200.83
200.84
200.85
200.86
200.87
200.88
202.30
202.31
202.32
202.33
202.34
202.35
202.36
202.37
202.38
238.77
238.8
239.9

Diagnostic Work Up
Test/Exam:
Clinical Assessment/Evaluation Including:
~ History & Physical
~ Nodal areas
~ B Cell Symptoms
~ Splenomegaly
~ Hepatomegaly
~ Staging and IPI Annotation
CBC
Chemistry Panel
LDH
Uric Acid
LFTs
Hepatitis B and C testing
HIV testing
H Pylori tests: urea breath test, serology
Flow PBL (Optional)
beta2microglobulin (Optional)
Ig level (Optional)
Beta HCG when applicable (Optional)
Lymph node tissue biopsy (FNA not sufficient)
Bone marrow biopsy (bilateral or unilateral) if > 2 cm core
Immunophenotype:
~ IHC: CD3, CD5, CD10, CD19, CD20, CD21, CD23, BCl- 2, BCl- 6, KI67, cyclin D1
~ Flow cytometry: kappa/lambda, CD3, CD5, CD10, CD19, CD20, CD23
Molecular studies (as needed/indicated):
~ BCR rearrangement
~ FISH/PCR: t(11;18), t(1;14), (BcI-10)
CT Chest/Abdomen/Pelvis with contrast
PET Scan
Muga Scan
EUS (Optional)

Prognostic Work Up

Non Gastric MALT - Extra-nodal Marginal Zone Lymphoma

ICD 9 Codes
199.2
200.00
200.01
200.02
200.03
200.04
200.05
200.06
200.07
200.08
200.10
200.11
200.12
200.13
200.14
200.15
200.16
200.17
200.18
200.30
200.31
200.32
200.33
200.34
200.35
200.36
200.37
200.38
200.50
200.51
200.52
200.53
200.54
200.55
200.56
200.57
200.58
200.60
200.61
200.62
200.63
200.64
200.65
200.66
200.67
200.68
200.80
200.81
200.82
200.83
200.84
200.85
200.86
200.87
200.88
202.30
202.31
202.32
202.33
202.34
202.35
202.36
202.37
202.38
238.77
238.8
239.9

Diagnostic Work Up
Test/Exam:
Clinical Assessment/Evaluation Including:
~ History & Physical
~ Nodal areas
~ B Cell Symptoms
~ Splenomegaly
~ Hepatomegaly
~ Staging and IPI Annotation
CBC
Chemistry Panel
LDH
Uric Acid
LFTs
Hepatitis B and C testing
HIV testing
Flow PBL (Optional)
beta2microglobulin (Optional)
Ig level (Optional)
Beta HCG when applicable (Optional)
Lymph node tissue biopsy (FNA not sufficient)
Bone marrow biopsy (bilateral or unilateral) if > 2 cm core
Immunophenotype:
~ IHC: CD3, CD5, CD10, CD19, CD20, CB21, CD23, BCl- 2, BCl- 6, MIB1 (KI- 67), cyclin D1
~ Flow cytometry: kappa/lambda, CD3, CD5, CD10, CD19, CD20, CD45
Molecular studies (as needed/indicated):
~ BCR, BcI- 2, BcI- 1 rearrangement
~ FISH/cytogenetics: t(14;18), t(11;18), t(1;14)
CT Chest/Abdomen/Pelvis with contrast
PET Scan
Muga Scan
CT Neck with contrast (Optional)
MRI Sinus/Orbits/Base of Skull if indicated (Optional)
skin MZL: Lyme serology (Borrelia burgdorferi)
MALT conjunctiva: Chlamydia

Prognostic Work Up

Small Lymphocytic Lymphoma/SLL/CLL

ICD 9 Codes
199.2
200.00
200.01
200.02
200.03
200.04
200.05
200.06
200.07
200.08
200.10
200.11
200.12
200.13
200.14
200.15
200.16
200.17
200.18
200.50
200.51
200.52
200.53
200.54
200.55
200.56
200.57
200.58
200.60
200.61
200.62
200.63
200.64
200.65
200.66
200.67
200.68
200.80
200.81
200.82
200.83
200.84
200.85
200.86
200.87
200.88
202.00
202.01
202.02
202.03
202.04
202.05
202.06
202.07
202.08
202.30
202.31
202.32
202.33
202.34
202.35
202.36
202.37
202.38
238.77
238.8
239.9

Diagnostic Work Up
Test/Exam:
Clinical Assessment/Evaluation Including:
~ History & Physical
~ Nodal areas
~ B Cell Symptoms
~ Splenomegaly
~ Hepatomegaly
~ Staging IPI in SLL/Rai or Binet in CLL
CBC
Chemistry Panel
LDH
Uric Acid
LFTs
Hepatitis B and C testing
HIV testing
beta2microglobulin (Optional)
Ig level (Optional)
Beta HCG when applicable (Optional)
Lymph node tissue biopsy (FNA not sufficient)
Bone marrow biopsy (bilateral or unilateral) if > 2 cm core
Immunophenotype:
~ IHC: CD3, CD5, CD10, CD19, CD20, CD21, CD23, BCl- 2, cyclin D1
~ Flow cytometry: kappa/lambda, CD3, CD5, CD10, CD19, CD20, CD38, ZAP- 70
Molecular studies (as needed/indicated):
~ PCR: somatic mutations
~ FISH panel/cytogenetics: p53 deletion, tris 12, del q13, t(11;14)
CT Chest/Abdomen/Pelvis with contrast
PET Scan
Muga Scan
CT Neck with contrast (Optional)
MRI Sinus/Orbits/Base of Skull if indicated (Optional)
Hemolysis: Coombs

Prognostic Work Up

Mantle Cell Lymphoma

199.2
200.00
200.01
200.02
200.03
200.04
200.05
200.06
200.07
200.08
200.10
200.11
200.12
200.13
200.14
200.15
200.16
200.17
200.18
200.40
200.41
200.42
200.43
200.44
200.45
200.46
200.47
200.48
200.50
200.51
200.52
200.53
200.54
200.55
200.56
200.57
200.58
200.60
200.61
200.62
200.63
200.64
200.65
200.66
200.67
200.68
200.80
200.81
200.82
200.83
200.84
200.85
200.86
200.87
200.88
202.00
202.01
202.02
202.03
202.04
202.05
202.06
202.07
202.08
202.30
202.31
202.32
202.33
202.34
202.35
202.36
202.37
202.38
238.77
238.8
239.9

Diagnostic Work Up
Test/Exam:
Clinical Assessment/Evaluation Including:
~ History & Physical
~ Nodal areas
~ B Cell Symptoms
~ Splenomegaly
~ Hepatomegaly
~ Staging and IPI Annotation, MIPI new model
CBC
Chemistry Panel
LDH
Uric Acid
LFTs
Hepatitis B and C testing
HIV testing
Flow PBL (Optional)
beta2microglobulin (Optional)
Ig level (Optional)
Beta HCG when applicable (Optional)
Lymph node tissue biopsy (FNA not sufficient)
Bone marrow biopsy (bilateral or unilateral) if > 2 cm core
Immunophenotype:
~ IHC: CD3, CD5, CD10, CD19, CD20, CD21, CD23, BCl- 2, BCl- 6, MIB1 (KI- 67), cyclin D1
~ Flow cytometry: kappa/lambda, CD3, CD5, CD10, CD19, CD20, CD45
Molecular studies (as needed/indicated):
~ BcI- 1 rearrangement
~ FISH/cytogenetics: t(11;14)/optional FISH panel ATM and p53 deletion
CT Chest/Abdomen/Pelvis with contrast
PET Scan
Muga Scan
CT Neck with contrast (Optional)
MRI Sinus/Orbits/Base of Skull if indicated (Optional)
Endoscopies: upper and lower GI evaluation. Not initial work up, but for restaging (R/O residual GI involvement)
CSF evaluation (and prophylaxis) in the following situations:
~ Location: testicular, breast, renal, sinus, paraspinal, peri-orbital
~ Subtype: blastoid variant

Prognostic Work Up

Burkitt's Lymphoma

ICD 9 Codes
199.2
200.20
200.21
200.22
200.23
200.24
200.25
200.26
200.27
200.28
202.00
202.01
202.02
202.03
202.04
202.05
202.06
202.07
202.08
202.30
202.31
202.32
202.33
202.34
202.35
202.36
202.37
202.38
238.77
238.8
239.9

Diagnostic Work Up
Test/Exam:
Clinical Assessment/Evaluation Including:
~ History & Physical
~ Nodal areas
~ B Cell Symptoms
~ Splenomegaly
~ Hepatomegaly
~ Staging and IPI Annotation
CBC
Chemistry Panel
LDH
Uric Acid
LFTs
Hepatitis B and C testing
HIV testing
Flow PBL (Optional)
beta2microglobulin (Optional)
Ig level (Optional)
Beta HCG when applicable (Optional)
CD4 count when applicable (Optional)
Lymph node tissue biopsy (FNA not sufficient)
Bone marrow biopsy (bilateral or unilateral) if > 2 cm core
Immunophenotype:
~ IHC: CD3, CD5, CD10, CD19, CD20, BCl- 2, BCl- 6, MIB1 (KI- 67), TdT
~ Flow cytometry: kappa/lambda, CD3, CD5, CD10, CD19, CD20, CD21, TdT
Molecular studies required:
~ c-MYC rearrangement
~ FISH/cytogenetics: t(8;14) or variants
~ EBV/EBER
CT Chest/Abdomen/Pelvis with contrast
PET Scan
Muga Scan
CT Neck with contrast (Optional)
MRI Sinus/Orbits/Base of Skull if indicated (Optional)
Endoscopies: upper GI evaluation if tonsil involvement
CSF evaluation (and prophylaxis) in all cases

Prognostic Work Up

Lymphoblastic Lymphoma

ICD 9 Codes
199.2
200.00
200.01
200.02
200.03
200.04
200.05
200.06
200.07
200.08
200.10
200.11
200.12
200.13
200.14
200.15
200.16
200.17
200.18
200.50
200.51
200.52
200.53
200.54
200.55
200.56
200.57
200.58
200.60
200.61
200.62
200.63
200.64
200.65
200.66
200.67
200.68
202.00
202.01
202.02
202.03
202.04
202.05
202.06
202.07
202.08
202.30
202.31
202.32
202.33
202.34
202.35
202.36
202.37
202.38
202.80
202.81
202.82
202.83
202.84
202.85
202.86
202.87
202.88
238.77
238.8
239.9

Diagnostic Work Up
Test/Exam:
Clinical Assessment/Evaluation Including:
~ History & Physical
~ Nodal areas
~ B Cell Symptoms
~ Splenomegaly
~ Hepatomegaly
~ Staging
~ Petechia, bleeding, CNS or testes involvement, effusion (cytology and flow)
CBC
Chemistry Panel
LDH
Uric Acid
LFTs
Hepatitis B and C testing
HIV testing
Flow PBL (Optional)
beta2microglobulin (Optional)
Ig level (Optional)
Beta HCG when applicable (Optional)
Lymph node tissue biopsy (FNA not sufficient)
Bone marrow biopsy (bilateral or unilateral) if > 2 cm core
Immunophenotype:
~ IHC: CD2, CD3, CD5, CD 7, CD10, CD1a, CD19, CD20, TdT, sIg
~ Flow cytometry: kappa/lambda, CD1a, CD3, CD5, CD4, CD7, CD8, CD10, CD13, CD14, CD33, CD19, CD20, CD21, CD22, TdT
Molecular studies required:
~ FISH/cytogenetics: t(8;14) or variants, t(9;22), TCR loci alpha delta at 14q11.2, or beta locus 7q35
CT Chest/Abdomen/Pelvis with contast
PET Scan
Muga Scan
MRI Brain
CT Neck with contrast (Optional)
CSF evaluation (and prophylaxis) in all cases

Prognostic Work Up

AIDS related Lymphoma

ICD 9 Codes
042 (AIDS Code)
200-202 (Lymphoma Code)

Diagnostic Work Up
Test/Exam:
Clinical Assessment/Evaluation Including:
~ History & Physical
~ Nodal areas
~ B Cell Symptoms
~ Splenomegaly
~ Hepatomegaly
~ Staging and IPI Annotation
CBC
Chemistry Panel
LDH
Uric Acid
LFTs
Hepatitis B and C testing
HIV testing
HIV viral load
CD4 count
EBV
CMV DNA
HHV8
beta2microglobulin (Optional)
Ig level (Optional)
Beta HCG when applicable (Optional)
Lymph node tissue biopsy (FNA not sufficient)
Bone marrow biopsy (bilateral or unilateral) if > 2 cm core
Immunophenotype:
~ IHC: CD3, CD5, CD10, CD19, CD20, BCl- 2, BCl- 6, MIB1 (KI- 67), MUM-1, CD138
~ Flow cytometry: kappa/lambda, CD3, CD5, CD10, CD19, CD20, CD45, TdT
Molecular studies (as needed/indicated):
~ BCR, BcI- 2, BcI- 6, c-MYC rearrangements
~ FISH/cytogenetics: t(14;18), t(3;v), t(8;14)
~ EBER on tissue
CT Chest/Abdomen/Pelvis with contrast
PET Scan
Muga Scan
CT Neck with contrast (Optional)
MRI Sinus/Orbits/Base of Skull if indicated (Optional)
Endoscopies: upper GI evaluation if tonsil involvement
CSF evaluation (and prophylaxis) in all cases

Prognostic Work Up

Peripheral T-cell Lymphoma

ICD 9 Codes
199.2
200.00
200.01
200.02
200.03
200.04
200.05
200.06
200.07
200.08
200.10
200.11
200.12
200.13
200.14
200.15
200.16
200.17
200.18
200.50
200.51
200.52
200.53
200.54
200.55
200.56
200.57
200.58
200.60
200.61
200.62
200.63
200.64
200.65
200.66
200.67
200.68
200.80
200.81
200.82
200.83
200.84
200.85
200.86
200.87
200.88
202.30
202.31
202.32
202.33
202.34
202.35
202.36
202.37
202.38
202.70
202.71
202.72
202.73
202.74
202.75
202.76
202.77
202.78
238.77
238.8
239.9

Diagnostic Work Up
Test/Exam:
Clinical Assessment/Evaluation Including:
~ History & Physical
~ Nodal areas
~ B Cell Symptoms
~ Splenomegaly
~ Hepatomegaly
~ Staging and IPI Annotation
CBC
Chemistry Panel
LDH
Uric Acid
LFTs
Hepatitis B and C testing
HIV testing
HTLV1
beta2microglobulin (Optional)
Ig level (Optional)
Beta HCG when applicable (Optional)
ANA (Optional)
Coombs in AILD (Optional)
Lymph node tissue biopsy (FNA not sufficient)
Bone marrow biopsy (bilateral or unilateral) if > 2 cm core
Immunophenotype:
~ IHC: CD2, CD3, CD5, CD10, CD19, CD20, CD4, CD8, CD7, CD30, BCl- 2, BCl- 6, MIB1 (KI- 67), ALK-1
~ Flow cytometry: kappa/lambda, CD2, CD3, CD5, CD10, CD19, CD20, CD4, CD8, CD7, CD30
Molecular studies (as needed/indicated):
~ TCR rearrangements
~ FISH/cytogenetics: t(2;5)
~ EBER on tissue, CXCL-13
~ Skin biopsies
CT Chest/Abdomen/Pelvis with contrast
PET Scan
Muga Scan
CT Neck with contrast (Optional)
MRI Sinus/Orbits/Base of Skull if indicated (Optional)
Bone scan or survey (Optional)
CSF evaluation (and prophylaxis) in the following situations:
~ Location: testicular, breast, renal, sinus, paraspinal, peri-orbital
~ Extra nodal disease with 2 to 3 sites, extensive bone marrow involvement

Prognostic Work Up

Mycosis Fungoides - Sezary Syndrome

ICD 9 Codes
199.2
202.10
202.11
202.12
202.13
202.14
202.15
202.16
202.17
202.18
202.20
202.21
202.22
202.23
202.24
202.25
202.26
202.27
202.28
202.30
202.31
202.32
202.33
202.34
202.35
202.36
202.37
202.38
238.77
238.8
239.9

Diagnostic Work Up
Test/Exam:
Clinical Assessment/Evaluation Including:
~ History & Physical
~ Nodal areas
~ B Cell Symptoms
~ Splenomegaly
~ Hepatomegaly
~ Skin lesions erythema
~ Plaques
~ Staging TNM
CBC
Chemistry Panel
LDH
Uric Acid
LFTs
Hepatitis B and C testing
HIV testing
HTLV1
beta2microglobulin (Optional)
Ig level (Optional)
Beta HCG when applicable (Optional)
Lymph node tissue biopsy (FNA not sufficient)
Bone marrow biopsy (bilateral or unilateral) if > 2 cm core
Immunophenotype:
~ IHC: CD2, CD3, CD5, CD10, CD19, CD20, CD4, CD8, CD7, CD30, BCl- 2, BCl- 6, MIB1 (KI- 67), ALK-1
~ Flow cytometry: kappa/lambda, CD2, CD3, CD5, CD10, CD19, CD20, CD4, CD8, CD7, CD30
Molecular studies (as needed/indicated):
~ TCR rearrangements
~ FISH/cytogenetics: t(2;5)
~ EBER on tissue, CXCL-13
~ Skin biopsies
CT Chest/Abdomen/Pelvis with contrast
PET Scan
Muga Scan
CT Neck with contrast (Optional)
MRI Sinus/Orbits/Base of Skull if indicated (Optional)
Bone scan or survey (Optional)
CSF evaluation (and prophylaxis) in the following situations:
~ Location: testicular, breast, renal, sinus, paraspinal, peri-orbital
~ Extra nodal disease with 2 to 3 sites, extensive bone marrow involvement

Prognostic Work Up

Hodgkin Lymphoma

ICD 9 Codes
199.2
200.70
200.71
200.72
200.73
200.74
200.75
200.76
200.77
200.78
201.10
201.11
201.12
201.13
201.14
201.15
201.16
201.17
201.18
201.20
201.21
201.22
201.23
201.24
201.25
201.26
201.27
201.28
201.40
201.41
201.42
201.43
201.44
201.45
201.46
201.47
201.48
201.50
201.52
201.53
201.54
201.55
201.56
201.57
201.58
201.60
201.61
201.62
201.63
201.64
201.65
201.66
201.67
201.68
201.70
201.71
201.72
201.73
201.74
201.75
201.76
201.77
201.78
201.90
201.91
201.92
201.93
201.94
201.95
201.96
201.97
201.98
238.77
238.8
239.9

Diagnostic Work Up
Test/Exam:
Clinical Assessment/Evaluation Including:
~ History & Physical
~ Nodal areas
~ B Cell Symptoms
~ Splenomegaly
~ Hepatomegaly
~ Staging and IPS scoring system annotation
CBC
Chemistry Panel
LDH
Uric Acid
LFTs
Hepatitis B and C testing
HIV testing
beta2microglobulin (Optional)
Ig level (Optional)
Beta HCG when applicable (Optional)
Sed rate
Lymph node tissue biopsy (FNA not sufficient)
Bone marrow biopsy (bilateral or unilateral) if > 2 cm core
Immunophenotype:
~ IHC: CD15, CD30, CD20, LCA
~ Flow cytometry: kappa/lambda: no clonality
Molecular studies (as needed/indicated):
~ EBV
CT Chest/Abdomen/Pelvis with contrast
PET Scan
Muga Scan
Pulmonary Function Tests
CT Neck with contrast (Optional)
Sperm banking and ovary chemical protection when applicable

Prognostic Work Up

Extraordinary Cancer Care is
Multidisciplinary Giving you a team of disease-specific experts.	Personalized Meeting your individual biologic, social, and emotional needs.	Innovative Bringing you tomorrow's novel research breakthroughs today.	Associated With Superior Outcomes Improving your survival through state-of-the-art treatments and prevention.	And High Patient Satisfaction Exceeding your needs - and expectations - in a cost-effective manner.
Expect Nothing Less.

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Clinical Standards of Excellence

Extraordinary Cancer Care is

Expect Nothing Less.